The study sought to find out the relationship between vocational interest and re-entry of adolescents into school. Three hundred and three (303) adolescents from three educational institutions in Delta State were use for the study. Two research hypotheses and one research question were raised to guide the study. Three research instruments were used; they are the vocational interest inventory (VII), the socio-economic status instrument (SESI) and the instrument on re-entry into school by adolescents (IRIS). Data were analyzed using regression analysis.